Non-Disabling Acute Stroke

Among patients with minor non-disabling acute ischemic stroke:

• treatment with tPA (compared with aspirin) did not increase the likelihood of favorable functional outcome at 90 days. (However, very early study termination precludes any definitive conclusions). Of note, "non-disabling" was defined as NIHSS < 6 and as judged subjectively by the patient and provider

• If criteria are met: defer IV tPA and treat with ASA 325 mg

• See: PRISMS Trial 2018; doi:10.1001/jama.2018.8496